Basic Information
VIS ID
TVIS44013949
Fusion event
HTLV-1-ZDHHC9 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q26.1
Reference genome
GRCh37/hg19
Start
128952721/129818745 (Hg38)
End
128952721/129818745 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZDHHC9
miRNAs that regulate target gene
hsa-mir-330-5p ; hsa-mir-125a-5p ; hsa-mir-134-5p ; hsa-mir-6873-3p ; hsa-mir-514b-5p ; hsa-mir-513c-5p ; hsa-mir-1236-3p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-216b-5p ; hsa-mir-1273g-5p ; hsa-mir-199a-5p ; hsa-mir-199b-5p ; hsa-mir-203a-5p ; hsa-mir-361-3p ; hsa-mir-409-5p ; hsa-mir-4302 ; hsa-mir-4443 ; hsa-mir-6515-5p ; hsa-mir-671-5p ; hsa-mir-6894-5p ; hsa-mir-7154-3p ; hsa-mir-765 ; hsa-mir-766-5p
Nearest miRNA
hsa-let-7f-2/Upstream/8447692; hsa-mir-105-1/Downstream/4350633;
Nearest TSS
ENST00000429181/Upstream/38761; ENST00000498179/Downstream/5043;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/140203, chrX-CpG: 43/Downstream/24819
Upstream sequence
aaagaaacatttattaaagatgtagaaaaacgctcaggatagaatgttaaatgacaaaagcaggattaaaaactatcatgttacagtccaattttgcaga
Downstream sequence
aacactagtaggaaatatagcaaaatggagagtgaatttaggattaagttttatttatactttctgcacttcccatattttccacaatgaacatgtgtta
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate