Basic Information
VIS ID
TVIS44013951
Fusion event
HTLV-1-ANKHD1-EIF4EBP3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
139928278/140548693 (Hg38)
End
139928278/140548693 (Hg38)
Orient
+
Location type
Intronic
Target gene
ANKHD1-EIF4EBP3
miRNAs that regulate target gene
hsa-mir-6838-5p ; hsa-mir-6834-5p ; hsa-mir-3622b-5p ; hsa-mir-885-3p ; hsa-mir-6134 ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-6875-5p ; hsa-mir-3126-5p ; hsa-mir-5693 ; hsa-mir-4519 ; hsa-mir-4713-3p
Nearest miRNA
hsa-mir-10397/Upstream/2901044; hsa-mir-103a-1/Downstream/14978;
Nearest TSS
ENST00000502646/Upstream/1027; ENST00000623481/Downstream/2435;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/787, chr5-CpG: 43/Downstream/8477
Upstream sequence
ACCTGAACTCAAAGTTTGGTGTTCCTCTTAGAGCCAAGATCTGAAGCTCTCCCAAACATAAAGCCCCTGCCTATACCAGCTGGGATGCCCCCCTTGCTTT
Downstream sequence
ATACCCACATCTTGGTTAGGTCTGGAAGATTTTAAGCACTATGAAGGCTTGTCTGCTGAGAACCTAGCTGGGCTTCAGAGCCGATGTCCTTTGATACACA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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