VISDB - VIS Detail

Basic Information

VIS ID

TVIS44013961

Fusion event

HTLV-1-MAP2K3 integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2014

PubMed ID

24735963

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr17

Cytoband

p11.2

Reference genome

GRCh37/hg19

Start

21207320/21304008 (Hg38)

End

21207320/21304008 (Hg38)

Orient

Location type

Intronic

Target gene

MAP2K3

miRNAs that regulate target gene

hsa-mir-214-3p ; hsa-mir-20a-5p ; hsa-mir-124-3p ; hsa-mir-30a-5p ; hsa-mir-21-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-218-5p ; hsa-mir-1227-5p ; hsa-mir-128-1-5p ; hsa-mir-128-2-5p ; hsa-mir-1296-3p ; hsa-mir-15a-5p ; hsa-mir-15b-5p ; hsa-mir-16-5p ; hsa-mir-195-5p ; hsa-mir-28-5p ; hsa-mir-2861 ; hsa-mir-3139 ; hsa-mir-3151-5p ; hsa-mir-3619-5p ; hsa-mir-424-5p ; hsa-mir-4270 ; hsa-mir-4441 ; hsa-mir-4456 ; hsa-mir-4481 ; hsa-mir-4512 ; hsa-mir-4743-5p ; hsa-mir-4745-5p ; hsa-mir-497-5p ; hsa-mir-541-3p ; hsa-mir-5571-3p ; hsa-mir-6081 ; hsa-mir-6510-5p ; hsa-mir-654-5p ; hsa-mir-6731-5p ; hsa-mir-6742-5p ; hsa-mir-6754-5p ; hsa-mir-6760-5p ; hsa-mir-6762-5p ; hsa-mir-6769a-5p ; hsa-mir-6769b-5p ; hsa-mir-6781-5p ; hsa-mir-6838-5p ; hsa-mir-6845-5p ; hsa-mir-6877-5p ; hsa-mir-708-5p ; hsa-mir-761 ; hsa-mir-8085 ; hsa-mir-92a-2-5p

Nearest miRNA

hsa-mir-1180/Upstream/1959434; hsa-mir-10226/Downstream/5989902;

Nearest TSS

ENST00000595228/Upstream/12539; ENST00000527123/Downstream/7679;

Nearest CpG islands

None/Target, chr17-CpG: 26/Upstream/18877, chr17-CpG: 47/Downstream/12671

Upstream sequence

CTTTACACACATCCCCATGGAGGGCACGGGGATGTGAGTGTCCTATGCGCATTTGTATGGAGAATCCCTGCTGGGCTGCTCTCCCATGCTGGTCTGTGGG

Downstream sequence

GACTCCATGTCCAAACACGCAGATCCTGCCTCCCAGGCTTTAATTGATCCTGCTGCCCTCTGGGAGCACCCACACAAGCCAGGCTCTCACTGGACCTCAT

Reference

Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.