Basic Information
VIS ID
TVIS44013990
Fusion event
HTLV-1-ARHGEF9 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q11.1
Reference genome
GRCh37/hg19
Start
62944038/63724158 (Hg38)
End
62944038/63724158 (Hg38)
Orient
-
Location type
Intronic
Target gene
ARHGEF9
miRNAs that regulate target gene
hsa-mir-574-5p ; hsa-mir-6867-5p ; hsa-mir-4711-3p ; hsa-mir-223-5p ; hsa-mir-297 ; hsa-mir-3177-5p ; hsa-mir-511-3p ; hsa-mir-567 ; hsa-mir-6817-3p ; hsa-mir-6873-3p ; hsa-mir-7110-3p
Nearest miRNA
hsa-let-7f-2/Upstream/8272576; hsa-mir-105-1/Downstream/61844;
Nearest TSS
ENST00000429181/Upstream/17798; ENST00000617377/Downstream/434;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/372611, chrX-CpG: 43/Downstream/30675
Upstream sequence
GAGAGGCAAAGAAGTAGACAGGAaggagagaagagcagaggagcaagaggaggagatgggaagaaactacgagaagaaagaataaaaaaaagatgagaaa
Downstream sequence
tagaaagcagaaaaaagagagataagaaagacaaaagTTCACAGCAATATAGGGTTAAAAAGTCTTATTCAAAAACCACCAAGGCCAACCCCAAAAGAGG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate