Basic Information
VIS ID
TVIS44013992
Fusion event
HTLV-1-ST6GAL2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
107462004/106845548 (Hg38)
End
107462004/106845548 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
ST6GAL2
miRNAs that regulate target gene
hsa-mir-5192 ; hsa-mir-4644 ; hsa-mir-4306 ; hsa-mir-7153-5p ; hsa-mir-185-5p ; hsa-mir-146b-5p ; hsa-mir-146a-5p ; hsa-mir-3925-5p ; hsa-mir-15b-3p ; hsa-mir-548f-3p ; hsa-mir-548e-3p ; hsa-mir-548az-3p ; hsa-mir-548ar-3p ; hsa-mir-548a-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-125a-3p ; hsa-mir-3529-3p ; hsa-mir-552-3p
Nearest miRNA
hsa-mir-1285-2/Upstream/4413182; hsa-mir-10b/Downstream/2295942;
Nearest TSS
ENST00000437798/Upstream/11084; ENST00000443833/Downstream/40465;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/2122, chr2-CpG: 196/Downstream/40349
Upstream sequence
ATACTCAGAAAGTAGGGTGATTCTGAGGGGAGGGTCTGCCAGGGGAAATGTGTGACCCCCACGATCCTTCCCCAGTACAGGCTGACCAATGCCAAAACAC
Downstream sequence
AAAGGCATGTAGGGCATGGCTGTAATACAATGGTTGTGTTTTCACTAAAAAAGATAGGAACTGAAatcaaaatgaatgttcctacctcaatgtggtcacc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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