Basic Information
VIS ID
TVIS44013995
Fusion event
HTLV-1-LRP1B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
142759691/142002122 (Hg38)
End
142759691/142002122 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
LRP1B
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-26b-5p ; hsa-mir-200c-3p ; hsa-mir-106b-3p ; hsa-mir-5692a
Nearest miRNA
hsa-mir-128-1/Upstream/1415437; hsa-mir-10b/Downstream/7328156;
Nearest TSS
ENST00000437798/Upstream/191721; ENST00000410015/Downstream/128883;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/3221042, chr2-CpG: 58/Downstream/128033
Nearest cancer related gene
LRP1B(TSG, No orient, 0)
Upstream sequence
AAAAAGGAAAATAATTACTTAACCTTAGCCAAAAGGATGGCCTCCAGTTTTGCTTAATTTCTACGTTCTTATGCTTTAGTAAAATATCACAAGTAGGAAC
Downstream sequence
CACtttaaaaagattttttaaaatttaattatatattGAGTGTGTCATGTGCCAAAAGGAGTCTATCTCGGGACATTAAGTAACCAGTATTGATCTATTA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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