Basic Information
VIS ID
TVIS44014000
Fusion event
HTLV-1-KIAA0319L integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p34.3
Reference genome
GRCh37/hg19
Start
36006382/35540781 (Hg38)
End
36006382/35540781 (Hg38)
Orient
+
Location type
Intronic
Target gene
KIAA0319L
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-128-3p ; hsa-mir-423-3p ; hsa-mir-432-5p ; hsa-mir-218-5p ; hsa-mir-5689 ; hsa-mir-571 ; hsa-mir-219a-1-3p ; hsa-mir-129-5p ; hsa-mir-6805-3p ; hsa-mir-5691 ; hsa-mir-431-5p ; hsa-mir-4294 ; hsa-mir-3194-3p ; hsa-mir-924
Nearest miRNA
hsa-mir-12136/Upstream/871087; hsa-mir-101-1/Downstream/1620782;
Nearest TSS
ENST00000473358/Upstream/33914; ENST00000459931/Downstream/14206;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/271527, chr1-CpG: 95/Downstream/16298
Upstream sequence
ttctattaagaccagcttgagacatcaaattgtctagtctcctacattcccaggattctgcaaagaagactaggtctctattgtcatggcattaccttgg
Downstream sequence
gaccctagggaagccTCAAACTCCTTGAAGGGAATCTTGATGTCAGCAATGCCATCCCTCTCAAAGGGAATTTCTGTTCCCTAAGAATGGCAAAGGTATT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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