VISDB - VIS Detail

Basic Information

VIS ID

TVIS44014003

Fusion event

HTLV-1-FAT3 integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2014

PubMed ID

24735963

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr11

Cytoband

q14.3

Reference genome

GRCh37/hg19

Start

92499999/92766833 (Hg38)

End

92499999/92766833 (Hg38)

Orient

Location type

Intronic

Target gene

FAT3

miRNAs that regulate target gene

hsa-mir-130b-3p ; hsa-mir-132-3p ; hsa-mir-19b-3p ; hsa-mir-16-5p ; hsa-mir-1303 ; hsa-mir-296-3p ; hsa-mir-6820-3p ; hsa-mir-3164 ; hsa-mir-4719 ; hsa-mir-522-3p ; hsa-mir-224-3p ; hsa-mir-374b-5p ; hsa-mir-374a-5p ; hsa-mir-603 ; hsa-mir-8485 ; hsa-mir-32-3p ; hsa-mir-4747-3p ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-6788-5p ; hsa-mir-1273h-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-6799-5p ; hsa-mir-7977 ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-4736 ; hsa-mir-3665 ; hsa-mir-383-3p ; hsa-mir-4717-5p ; hsa-mir-1295b-3p ; hsa-mir-1270 ; hsa-mir-1273e ; hsa-mir-3160-3p ; hsa-mir-3689d ; hsa-mir-4459 ; hsa-mir-4487 ; hsa-mir-455-3p ; hsa-mir-4683 ; hsa-mir-5186 ; hsa-mir-558 ; hsa-mir-5694 ; hsa-mir-6134 ; hsa-mir-620 ; hsa-mir-6499-3p ; hsa-mir-6516-5p ; hsa-mir-665 ; hsa-mir-6840-3p ; hsa-mir-6851-5p ; hsa-mir-6880-5p ; hsa-mir-3613-3p ; hsa-mir-3675-3p ; hsa-mir-4662a-5p ; hsa-mir-4676-5p ; hsa-mir-4684-5p ; hsa-mir-548c-3p ; hsa-mir-575 ; hsa-mir-6771-3p ; hsa-mir-6858-3p

Nearest miRNA

hsa-mir-10392/Upstream/1897631; hsa-let-7a-2/Downstream/966841;

Nearest TSS

ENST00000527297/Upstream/358657; ENST00000469900/Downstream/34;

Nearest CpG islands

None/Target, chr11-CpG: 30/Upstream/539967, chr11-CpG: 35/Downstream/99942

Upstream sequence

GGGTCTCCATTTCTTTATCTTCTTAGTAATTTTCAGCTCATTAAGATATTATCTGATGCAGTTTCTTCTTTCTTGGCACCACAAAGGGTTGCACGTAGTC

Downstream sequence

ATGGTCTGGTTTTCTGTACAGTCACCTTTAATGATTTCTTCACTTCCACCCCCAGAGTCACAGAAAGTGCAATTCAGTTCTTACACGTGCCCTTAGTGCC

Reference

Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.