Basic Information
VIS ID
TVIS44014008
Fusion event
HTLV-1-CHAC1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q15.1
Reference genome
End
41240553/40948355 (Hg38)
Orient
-
Location type
Intronic
Target gene
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-26a-5p ; hsa-mir-26b-5p ; hsa-mir-95-5p ; hsa-mir-142-5p ; hsa-mir-498 ; hsa-mir-561-3p ; hsa-mir-1297 ; hsa-mir-4465 ; hsa-mir-4697-3p ; hsa-mir-548at-5p ; hsa-mir-5590-3p ; hsa-mir-5697 ; hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-363-5p ; hsa-mir-424-5p ; hsa-mir-491-5p ; hsa-mir-497-5p ; hsa-mir-661 ; hsa-mir-374b-3p ; hsa-mir-1293 ; hsa-mir-3151-5p ; hsa-mir-3170 ; hsa-mir-4447 ; hsa-mir-4472 ; hsa-mir-4483 ; hsa-mir-4524a-5p ; hsa-mir-4524b-5p ; hsa-mir-6742-5p ; hsa-mir-6742-3p ; hsa-mir-6745 ; hsa-mir-6756-5p ; hsa-mir-6766-5p ; hsa-mir-6776-5p ; hsa-mir-6796-5p ; hsa-mir-6838-5p ; hsa-mir-6855-5p ; hsa-mir-7847-3p ; hsa-mir-211-3p ; hsa-mir-940 ; hsa-mir-1207-5p ; hsa-mir-1324 ; hsa-mir-3166 ; hsa-mir-3199 ; hsa-mir-4251 ; hsa-mir-4514 ; hsa-mir-4692 ; hsa-mir-4722-5p ; hsa-mir-4740-5p ; hsa-mir-4763-3p ; hsa-mir-4524b-3p ; hsa-mir-6165 ; hsa-mir-6733-3p ; hsa-mir-6808-5p ; hsa-mir-6857-3p ; hsa-mir-6868-5p ; hsa-mir-6893-5p ; hsa-mir-8052 ; hsa-mir-383-3p ; hsa-mir-503-5p ; hsa-mir-646 ; hsa-mir-4755-3p ; hsa-mir-4311 ; hsa-mir-656-5p ; hsa-mir-5006-5p ; hsa-mir-6501-5p ; hsa-mir-144-3p ; hsa-mir-194-5p ; hsa-mir-4298 ; hsa-mir-1302 ; hsa-mir-3972 ; hsa-mir-1202 ; hsa-mir-5196-5p ; hsa-mir-4747-5p ; hsa-mir-4646-5p ; hsa-mir-204-3p ; hsa-mir-6871-5p ; hsa-mir-4494 ; hsa-mir-4463 ; hsa-mir-212-3p ; hsa-mir-132-3p ; hsa-mir-539-5p ; hsa-mir-7109-3p ; hsa-mir-5001-5p ; hsa-mir-762 ; hsa-mir-4498 ; hsa-mir-4492 ; hsa-mir-4743-5p ; hsa-mir-6894-5p ; hsa-mir-765 ; hsa-mir-7154-3p ; hsa-mir-766-5p ; hsa-mir-5703 ; hsa-mir-4516 ; hsa-mir-4434 ; hsa-mir-4784 ; hsa-mir-3150b-3p ; hsa-mir-6770-5p ; hsa-mir-6784-5p ; hsa-mir-4446-3p ; hsa-mir-3154 ; hsa-mir-3650 ; hsa-mir-193b-5p ; hsa-mir-4302 ; hsa-mir-224-5p ; hsa-mir-5692a ; hsa-mir-328-5p ; hsa-mir-3663-5p ; hsa-mir-625-5p ; hsa-mir-637 ; hsa-mir-6795-5p ; hsa-mir-6885-5p ; hsa-mir-6887-5p ; hsa-mir-7109-5p ; hsa-mir-7152-3p
Nearest miRNA
hsa-mir-1233-1/Upstream/3975454; hsa-mir-10393/Downstream/743230;
Nearby gene
CHAC1(+5083) ;
Upstream sequence
TGCAAGAGAGTTAAATGGTCCAAAGAGAGTGATGGCTTCTCATTTTCTGTCCCTTACAGAGACTACAAATATCATTTCTTCTGGAATCTAGCACATTTCC
Downstream sequence
AAAATGCATCACTTATATTTTCCTCACAAGGCAGGCACACATTAAGCACGTGACAATCATATGATTTATTTGTGAGCCCCAGGGCTTCCAGGAGCTTTCC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate