Basic Information
VIS ID
TVIS44014009
Fusion event
HTLV-1-LRP1B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
141057413/140299844 (Hg38)
End
141057413/140299844 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
LRP1B
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-26b-5p ; hsa-mir-200c-3p ; hsa-mir-106b-3p ; hsa-mir-5692a
Nearest miRNA
hsa-mir-128-1/Upstream/4634366; hsa-mir-10b/Downstream/286782;
Nearest TSS
ENST00000437798/Upstream/1875; ENST00000410015/Downstream/58224;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1518764, chr2-CpG: 58/Downstream/1830311
Nearest cancer related gene
LRP1B(TSG, No orient, 0)
Upstream sequence
AAGTAATTCTTCAATTACAGTCAATGGATACCTTACAGAGATATAGAACAAGTAAATAGCAATAAAAATTACCATGAGCAAAACAATGAAATAAACAGTG
Downstream sequence
CGTAAAGTACAAAAACAAAGTACATTAGAACAATCTGAAAAGGTGCCACACAAACATATAATGTGATCACTGTGGATTCATTGTTTCCTATATGTGTTTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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