Basic Information
VIS ID
TVIS44014016
Fusion event
HTLV-1-RIMS1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q13
Reference genome
GRCh37/hg19
Start
72599456/71889753 (Hg38)
End
72599456/71889753 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA6D
Target gene
RIMS1
Nearest miRNA
hsa-mir-10398/Upstream/486132; hsa-mir-10524/Downstream/1077934;
Nearest TSS
ENST00000381078/Upstream/2729; ENST00000524197/Downstream/292999;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/2688, chr6-CpG: 100/Downstream/292581
Upstream sequence
TTTTTATAGGGGACACTTTATGTCTTAAAAACTGGGGATAATGGGAACTATTTAGATGACACATATATATGAGGACATAATGACACATAGTCATAGATGG
Downstream sequence
TGGCCTTTTTAAAACTTTGTGTTAAAATAGATTGGAAAACAGGATTCTTTTAACAGGGCTTTAAAATATTGTTACATCAGAGAAAAGTTTTTGTGGTAAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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