Basic Information
VIS ID
TVIS44014028
Fusion event
HTLV-1-ANXA11 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
81949115/80189359 (Hg38)
End
81949115/80189359 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D
Target gene
ANXA11
miRNAs that regulate target gene
hsa-mir-122-5p ; hsa-mir-335-5p ; hsa-mir-124-3p ; hsa-mir-7-5p ; hsa-mir-1301-3p ; hsa-mir-484 ; hsa-mir-324-3p ; hsa-mir-320a ; hsa-mir-92a-3p ; hsa-mir-25-3p ; hsa-mir-1224-5p ; hsa-mir-5579-3p ; hsa-mir-4751 ; hsa-mir-5004-5p ; hsa-mir-4538 ; hsa-mir-4453 ; hsa-mir-4741 ; hsa-mir-4675 ; hsa-mir-505-5p ; hsa-mir-3158-3p ; hsa-mir-4446-3p ; hsa-mir-5088-5p ; hsa-mir-570-5p ; hsa-mir-548ba ; hsa-mir-548ai ; hsa-mir-548ag ; hsa-mir-6891-5p ; hsa-mir-3173-3p ; hsa-mir-4428
Nearest miRNA
hsa-mir-1265/Upstream/4636806; hsa-mir-107/Downstream/6075335;
Nearest TSS
ENST00000439456/Upstream/16338; ENST00000432308/Downstream/15560;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/56451, chr10-CpG: 93/Downstream/15566
Upstream sequence
gaggaaaagggccaagtgccacggaactcaaatggcctctaaagctggaaagggcaaggaagcattcacctctagggccaccagacaaagacacaaccct
Downstream sequence
gccaacaccttcattttagcaccatgagatccaaaagaccctgagataaaactgtaaagataaaaaaaccatgtggtaaaatagtgcagccactatggaa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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