Basic Information
VIS ID
TVIS44014029
Fusion event
HTLV-1-ARRB1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.4
Reference genome
GRCh37/hg19
Start
75003057/75292013 (Hg38)
End
75003057/75292013 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
ARRB1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-98-5p ; hsa-mir-26b-5p ; hsa-mir-186-5p ; hsa-mir-92a-3p ; hsa-mir-525-3p ; hsa-mir-6763-5p ; hsa-mir-3150a-3p ; hsa-mir-6126 ; hsa-mir-491-5p ; hsa-mir-92a-2-5p ; hsa-mir-6825-5p ; hsa-mir-939-5p ; hsa-mir-1343-5p ; hsa-mir-3175 ; hsa-mir-7106-5p ; hsa-mir-765 ; hsa-mir-6804-5p ; hsa-mir-3913-3p ; hsa-mir-605-3p ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-4779 ; hsa-mir-574-5p ; hsa-mir-568 ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-642a-5p ; hsa-mir-3140-3p ; hsa-mir-6859-3p ; hsa-mir-4469 ; hsa-mir-2276-5p ; hsa-mir-6892-3p ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-6887-3p ; hsa-mir-4640-3p
Nearest miRNA
hsa-mir-10392/Upstream/571676; hsa-let-7a-2/Downstream/43079;
Nearest TSS
ENST00000527297/Upstream/7700; ENST00000534555/Downstream/11657;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/49567, chr11-CpG: 97/Downstream/59167
Upstream sequence
CCATGGCACATGGACAGCCACTCCTGCCTCCTTCCAGAAGAGAAGGCGAGTGGGTGGTGGCTCTGCGCTGCATTGATGGCCCTGGCCCTGCCCACCCTCA
Downstream sequence
CCTCTCACTTCTGGGCTGGCAGGAACCACTGATGAGTGTGAGCATGGCTTACTAAGAAGCCTGGCACATCCCGCCCCACCTCCCCTGGGAGCCCTGGGCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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