Basic Information
VIS ID
TVIS44014030
Fusion event
HTLV-1-UBASH3B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
122614109/122743401 (Hg38)
End
122614109/122743401 (Hg38)
Orient
+
Location type
Intronic
Target gene
UBASH3B
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-200a-3p ; hsa-mir-491-3p ; hsa-mir-192-3p ; hsa-mir-1227-3p ; hsa-mir-4275 ; hsa-mir-586 ; hsa-mir-3662 ; hsa-mir-455-5p ; hsa-let-7g-3p ; hsa-let-7a-2-3p ; hsa-mir-486-5p ; hsa-mir-4797-5p
Nearest miRNA
hsa-let-7a-2/Upstream/591093; hsa-mir-3167/Downstream/638039;
Nearest TSS
ENST00000527297/Upstream/34139; ENST00000533451/Downstream/30695;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/86630, chr11-CpG: 51/Downstream/139277
Upstream sequence
aactccagggctcatgtgatcctcccactcagcctctcaagtagctgggactacaggcatgcactaccatgcctagctaatttttttacttcttgtacag
Downstream sequence
ttgggggtctcgctatgttgctcaagctagtctcaaacttctgggctcaagtgaccctcctgcttcggcttccagagtttcgggattacaggaatgaacc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate