Basic Information
VIS ID
TVIS44014032
Fusion event
HTLV-1-MYO16 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q33.3
Reference genome
GRCh37/hg19
Start
109285266/108632918 (Hg38)
End
109285266/108632918 (Hg38)
Orient
-
Location type
Intronic
Target gene
MYO16
miRNAs that regulate target gene
hsa-mir-4695-3p ; hsa-mir-602 ; hsa-mir-8485 ; hsa-mir-548b-3p ; hsa-mir-3133
Nearest miRNA
hsa-mir-1267/Upstream/1101670; hsa-mir-4502/Downstream/1708040;
Nearest TSS
ENST00000623511/Upstream/3695; ENST00000467639/Downstream/32965;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/136247, chr13-CpG: 22/Downstream/494417
Upstream sequence
CCAGGCCCCAGCTGAGGCGCAAGCAGAAATGAGAAATGGAACTCAAGGGAGTCATGGGCTCACAGAACTTTAAGGCCATGTGAGACTTGAAACTACTTTT
Downstream sequence
GTTTTAATGAACTGAAGCGGAGGCTTGAGGTCTACCTGTGGAGTTCCCTTCACGTGCCTCTGGGGGTGAAGCATTGCAATAACTACACCTGACCTATTTC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate