Basic Information
VIS ID
TVIS44014049
Fusion event
HTLV-1-KNDC1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q26.3
Reference genome
GRCh37/hg19
Start
134988176/133174672 (Hg38)
End
134988176/133174672 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
KNDC1
miRNAs that regulate target gene
hsa-mir-550b-2-5p ; hsa-mir-581 ; hsa-mir-5695 ; hsa-mir-4432
Nearest miRNA
hsa-mir-107/Upstream/2212004; hsa-mir-202/Downstream/72839;
Nearest TSS
ENST00000439456/Upstream/7488; ENST00000304477/Downstream/55602;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/7117, chr10-CpG: 21/Downstream/4945
Upstream sequence
tggatgaatgaagggatggatgagtggatggccaggtggatggataggtggataggtgggtggatgggcaggtggatgggtgaatggacagatgatggtg
Downstream sequence
gatatgtggatggatgggtgggtagataggtggatggacagatagatggttaatatgtggatggatgggtggatggatgatgggtggatgaacaagtaga
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate