Basic Information
VIS ID
TVIS44014081
Fusion event
HTLV-1-FGF14 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q33.1
Reference genome
GRCh37/hg19
Start
102890339/102237989 (Hg38)
End
102890339/102237989 (Hg38)
Orient
-
Location type
Intronic
Target gene
FGF14
miRNAs that regulate target gene
hsa-mir-574-5p ; hsa-mir-4455 ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-511-3p ; hsa-mir-5010-3p ; hsa-mir-147a ; hsa-mir-6818-5p ; hsa-mir-8068
Nearest miRNA
hsa-mir-1297/Upstream/191985; hsa-mir-1267/Downstream/5293182;
Nearest TSS
ENST00000623511/Upstream/321344; ENST00000444686/Downstream/129550;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/320864, chr13-CpG: 60/Downstream/156341
Upstream sequence
CATCTATTGAGGAAATCTGTCTTGGCATTCACTCTAAACTGGTATTAAGGACACATATTACCTAAATAGTCATGTTTTTAAGATCTACTTAAGTTTCAAT
Downstream sequence
TATGCAGCTATTTATACTCCCCTAAATCTAGTTAGTTACCATTTATGTACCTGGGATGTGCTTCATGGGCAACGTTTTCTTTATTATCATTGAATTTGTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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