Basic Information
VIS ID
TVIS44014090
Fusion event
HTLV-1-SACS integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q12.12
Reference genome
GRCh37/hg19
Start
24005408/23431269 (Hg38)
End
24005408/23431269 (Hg38)
Orient
+
Location type
Intronic
Target gene
SACS
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-mir-26b-5p ; hsa-mir-1226-3p ; hsa-mir-424-5p ; hsa-mir-20a-5p ; hsa-mir-218-5p ; hsa-mir-106b-5p ; hsa-mir-4465 ; hsa-mir-26a-5p ; hsa-mir-1297 ; hsa-mir-5697 ; hsa-mir-3159 ; hsa-mir-5684 ; hsa-mir-216b-3p ; hsa-mir-6512-5p ; hsa-mir-302a-5p ; hsa-mir-30e-5p ; hsa-mir-30d-5p ; hsa-mir-30c-5p ; hsa-mir-30b-5p ; hsa-mir-30a-5p ; hsa-mir-93-5p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-4499/Upstream/2997423; hsa-mir-1267/Downstream/731147;
Nearest TSS
ENST00000623511/Upstream/12298; ENST00000575689/Downstream/2432;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/55643, chr13-CpG: 57/Downstream/35059
Upstream sequence
GAGGCTACCCCAAAGAGAGCTATCTGAATCATCTAGTCAGAACCTGAAGGAAATTGAAAGATTATTCTATGTCTCTTGCCTTAGAGATGGCGTTAAAAGG
Downstream sequence
CTTTCTAATTAGCACAAAGAGAAGTCAAAGCAGGGCTGGAGCCACACCCTTTGGTCCCCAATCCAGTGCTTTTCCCAACTTCGCTATGTTCCCCCTTAGG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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