Basic Information
VIS ID
TVIS44014092
Fusion event
HTLV-1-MTHFS integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
80143005/79850663 (Hg38)
End
80143005/79850663 (Hg38)
Orient
-
Location type
Intronic
Target gene
MTHFS
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-26b-5p
Nearest miRNA
hsa-mir-10393/Upstream/640792; hsa-mir-11181/Downstream/730440;
Nearest TSS
ENST00000557528/Upstream/5336; ENST00000618735/Downstream/46334;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/417362, chr15-CpG: 89/Downstream/46001
Upstream sequence
gcctgtggggctgcaatgtgataacccccatcatagaacataaggaaagagagtttcagggagagagaagtagacgcagtgtcaaatgtggcagaatgga
Downstream sequence
caagtaaggtaaggacacaaaaatatctattagatttggcaactagggaatcaccggggcaaggataatataagtggagagatggggacagatgcTGAGC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate