Basic Information
VIS ID
TVIS44014109
Fusion event
HTLV-1-NMRK1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q21.13
Reference genome
GRCh37/hg19
Start
77697394/75082478 (Hg38)
End
77697394/75082478 (Hg38)
Orient
-
Location type
Intronic
Target gene
NMRK1
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-7159-5p ; hsa-mir-3065-5p ; hsa-mir-8485 ; hsa-mir-603 ; hsa-mir-4801 ; hsa-mir-4731-3p ; hsa-mir-3941 ; hsa-mir-1228-3p ; hsa-mir-4789-3p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-377-3p
Nearest miRNA
hsa-mir-101-2/Upstream/4272394; hsa-let-7a-1/Downstream/8887270;
Nearest TSS
ENST00000422679/Upstream/15273; ENST00000346234/Downstream/5333;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/53799, chr9-CpG: 94/Downstream/5491
Upstream sequence
TACCATAACACAATGATTTCCCCAAAATTACAAACAAAGTAGTCTCAGATATTTTATTAATTGGGTCACAAACAATGTGAATATACTTAGAGTAAAGGTG
Downstream sequence
AACATAATATGGTAGCAAAACAAATAATGTCATTTTCAGTTGATGTTGATGTTTTATTTGCATGCCTGCCTATGGCACCACAGGTAGGATGACCATATAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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