Basic Information
VIS ID
TVIS44014137
Fusion event
HTLV-1-BACH2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q15
Reference genome
GRCh37/hg19
Start
90754491/90044772 (Hg38)
End
90754491/90044772 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA6G
Target gene
BACH2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-29c-3p ; hsa-mir-615-3p ; hsa-mir-8064 ; hsa-mir-1277-5p ; hsa-mir-190a-3p ; hsa-mir-6083 ; hsa-mir-5011-5p ; hsa-mir-656-3p ; hsa-mir-410-3p ; hsa-mir-3942-3p ; hsa-mir-1324 ; hsa-mir-8485 ; hsa-mir-6797-3p ; hsa-mir-6076 ; hsa-mir-6807-3p ; hsa-mir-217 ; hsa-mir-509-5p ; hsa-mir-509-3-5p ; hsa-mir-4418 ; hsa-mir-6749-3p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-2355-5p ; hsa-mir-15b-3p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-6832-3p ; hsa-mir-620 ; hsa-mir-1270 ; hsa-mir-4531 ; hsa-mir-5703 ; hsa-mir-4516 ; hsa-mir-4434 ; hsa-mir-5695 ; hsa-mir-3145-5p ; hsa-let-7g-3p ; hsa-let-7a-2-3p ; hsa-mir-374b-5p ; hsa-mir-374a-5p ; hsa-mir-4791 ; hsa-mir-3201 ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-369-3p ; hsa-mir-5583-3p ; hsa-mir-4517 ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-4726-3p ; hsa-mir-6764-5p ; hsa-mir-1915-3p ; hsa-mir-6840-3p ; hsa-mir-142-5p
Nearest miRNA
hsa-mir-10398/Upstream/11505463; hsa-mir-1202/Downstream/267970;
Nearest TSS
ENST00000381078/Upstream/35945; ENST00000569865/Downstream/173473;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/156838, chr6-CpG: 227/Downstream/250304
Upstream sequence
aaagtggtgacaaagtgcctggatttgacaggtggagctgacgggatttgctagtggattggatgtggggtgagagaacggaaagagttaacgatggcac
Downstream sequence
caaggatttcagcttaagtgaccagatgaatgggggtgtcatttattgaaagaggaaaccccagaggaggatcaggtatgggggatgagggcagaacaag
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate