Basic Information
VIS ID
TVIS44014153
Fusion event
HTLV-1-EHF integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p13
Reference genome
GRCh37/hg19
Start
34683791/34662244 (Hg38)
End
34683791/34662244 (Hg38)
Orient
-
Location type
UTR3
Fragile sites / regions
FRA11E
Target gene
EHF
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-210/Upstream/6184696; hsa-let-7a-2/Downstream/279593;
Nearest TSS
ENST00000527297/Upstream/19617; ENST00000533262/Downstream/228497;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/222934, chr11-CpG: 98/Downstream/253537
Nearest cancer related gene
EHF(TSG, No orient, 0)
Upstream sequence
tagcatgggacaagtacacaacacatatttgttcaatgaatgaatGAATGTCTTCTAAAAGACTCCTCTGATTGGGAGACCATATCTATAATTGGGATGT
Downstream sequence
GAATCATTTCTTCAGTGGAATAAGAGCACAACGGCACAACCTTCAAGGACATATTATCTACTATGAACATTTTACTGTGAGACTCTTTATTTTGCCTTCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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