Basic Information
VIS ID
TVIS44014167
Fusion event
HTLV-1-GALNT13 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
155194132/154337620 (Hg38)
End
155194132/154337620 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
GALNT13
miRNAs that regulate target gene
hsa-mir-129-5p ; hsa-mir-6868-3p ; hsa-mir-942-5p ; hsa-mir-130b-5p ; hsa-mir-1237-3p ; hsa-mir-561-3p
Nearest miRNA
hsa-mir-128-1/Upstream/2969209; hsa-mir-10b/Downstream/4849215;
Nearest TSS
ENST00000437798/Upstream/36041; ENST00000494805/Downstream/71391;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/464215, chr2-CpG: 141/Downstream/359873
Upstream sequence
atattttaaaacccataagcataccacatagtgataattattaacattttagtgcttagcatttcagcttttgttgtatgaatatttaaatgtacatttt
Downstream sequence
gttataaatatggaattataattgttaaatatttttgagcaatgtattttacatttttccataggccatatacagtaaatattaattgcccaagtcaaaa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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