Basic Information
VIS ID
TVIS44014170
Fusion event
HTLV-1-FHIT integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p14.2
Reference genome
GRCh37/hg19
Start
60015408/60029682 (Hg38)
End
60015408/60029682 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA3B
Target gene
FHIT
miRNAs that regulate target gene
hsa-mir-143-3p ; hsa-mir-217 ; hsa-mir-331-3p ; hsa-mir-625-5p
Nearest miRNA
hsa-let-7g/Upstream/4177088; hsa-mir-12124/Downstream/588123;
Nearest TSS
ENST00000440867/Upstream/15532; ENST00000475527/Downstream/51158;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/979464, chr3-CpG: 48/Downstream/1221250
Nearest cancer related gene
FHIT(TSG, No orient, 0)
Upstream sequence
CTCTTTTGTTTCCCAAGTAGCCTGAGAACTGCATGTTACtgtctacctaaataacagaggctctctaaaagaaaatgatatttattgagaaatgggcctt
Downstream sequence
gtcttgggaatacatgtgccacagtaaattatgagtattcagccaggtgaaggaagacaaaggtttttaaagggcaagtgaggagaattacctaattgtt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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