Basic Information
VIS ID
TVIS44014189
Fusion event
HTLV-1-PHF20L1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.22
Reference genome
GRCh37/hg19
Start
133845139/132832894 (Hg38)
End
133845139/132832894 (Hg38)
Orient
-
Location type
Intronic
Target gene
PHF20L1
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-21-5p ; hsa-mir-769-3p ; hsa-mir-629-3p ; hsa-mir-6867-3p ; hsa-mir-4713-5p ; hsa-mir-6832-3p ; hsa-mir-6756-3p ; hsa-mir-3127-3p ; hsa-mir-132-3p ; hsa-mir-212-3p ; hsa-mir-6830-3p
Nearest miRNA
hsa-mir-1204/Upstream/2824441; hsa-mir-10400/Downstream/213587;
Nearest TSS
ENST00000518652/Upstream/15486; ENST00000493126/Downstream/3451;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/57104, chr8-CpG: 126/Downstream/463429
Upstream sequence
tagataatgctttcttaaATAAACATTTATGGTAATCTTAAAAGTATACTTTGAATTCCTGGTCAGATACATCTGTAACCAAAGTCCTGAGATGTAGTCA
Downstream sequence
GACAACTGATTTAAACACAGGCAGGAACTAAGCGCCCTTAGGTAGTCAGAAGGCCACGTCAGCAGTGAAGGGAGCACTGGAGTTCAAATCTGTTAGACTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate