Basic Information
VIS ID
TVIS44014191
Fusion event
HTLV-1-NRK integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
105073328/105829335 (Hg38)
End
105073328/105829335 (Hg38)
Orient
+
Location type
Intronic
Target gene
NRK
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-let-7f-2/Upstream/10766109; hsa-mir-105-1/Downstream/810479;
Nearest TSS
ENST00000429181/Upstream/6754; ENST00000540278/Downstream/119103;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/6218, chrX-CpG: 33/Downstream/782463
Upstream sequence
GTAATCCCAAAGCTGTGTCATTTTCCTATGACAGTTTTGCTAGATTACACAAATATCACGGCAGTTTTAAGGAGTTTATAATTTCATTCATCTAAGTTGC
Downstream sequence
ATATGCTCAATAGTTTTCCTGTTTAGCTTATATTTATCACAGCAATAAAAATGTTTTCAAACAGGATTAAACAACGTTTGTGTATATAAAATAAACTTTC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate