Basic Information
VIS ID
TVIS44014193
Fusion event
HTLV-1-SPIRE2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
89918310/89851902 (Hg38)
End
89918310/89851902 (Hg38)
Orient
-
Location type
Intronic
Target gene
SPIRE2
miRNAs that regulate target gene
hsa-mir-6778-3p ; hsa-mir-3137 ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-331-3p ; hsa-mir-6810-3p ; hsa-mir-6801-3p ; hsa-mir-4279 ; hsa-mir-6749-3p ; hsa-mir-4469 ; hsa-mir-5193 ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-498 ; hsa-mir-378a-5p ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-4532 ; hsa-mir-1247-3p
Nearest miRNA
hsa-mir-11401/Upstream/1135565;
Nearest TSS
ENST00000527434/Upstream/2036; ENST00000561883/Downstream/2420;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/1118, chr16-CpG: 24/Downstream/724
Upstream sequence
GGCAGAAGGTGTTTTCGAAGTTAACTAGTGCTGGTCTGTCATTCCTCCCTGACCCTTTATGGTGCTGTGTCTCTCCTGTCCTCTAACCGAGGAAGGTTCC
Downstream sequence
TGGCCAGCTTCCCGAACCCTCTGAGCCTTTGCAGGTGGTTTTGACGCCGGGTGGCAGCCTGAGCTGCTCGGCCTCATCTGCAGCCCAAGCGTGTGCCAAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate