Basic Information
VIS ID
TVIS44014194
Fusion event
HTLV-1-ADCY8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.22
Reference genome
GRCh37/hg19
Start
131949956/130937710 (Hg38)
End
131949956/130937710 (Hg38)
Orient
+
Location type
Intronic
Target gene
ADCY8
Nearest miRNA
hsa-mir-1204/Upstream/929257; hsa-mir-10400/Downstream/2108771;
Nearest TSS
ENST00000518652/Upstream/2301; ENST00000519005/Downstream/53155;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/493671, chr8-CpG: 207/Downstream/102293
Upstream sequence
TAGTAAGCACTTAAAAATGTACATCACTTAGGAATTCCTATTACTTCAACTCTATAAAGTTCCTTTCCAGCAAGGACATTTGCACTTTATGAGGAGGAAC
Downstream sequence
TAAGTCTTCTTATATATCCTTTTATTCGTTTATTAATTTATATGTTTGTTCATTGAAAAAATTAAAAATCAATTGGGCACCTATAATAAGGCAAACATTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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