Basic Information
VIS ID
TVIS44014199
Fusion event
HTLV-1-TASP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
13316811/13336164 (Hg38)
End
13316811/13336164 (Hg38)
Orient
+
Location type
Intronic
Target gene
TASP1
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-4503 ; hsa-mir-100-3p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-15b-5p
Nearest miRNA
hsa-mir-103a-2/Upstream/2686469; hsa-mir-1-1/Downstream/5134451;
Nearest TSS
ENST00000382410/Upstream/90795; ENST00000469177/Downstream/32539;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/36864, chr20-CpG: 43/Downstream/302474
Nearby gene
ISM1(+35514) ;
Upstream sequence
acgcttccaggaaggaaaaaaacacattacatagaaaagaatacaaatccaaaaggcttctcaataacaGTAAGTTTCCAGGGGGCCCAAAGGAGAATGA
Downstream sequence
GTTTCAACcagggctgcttcctgggtgtgctaccactgacatcacatagggccccgcattcagaagggggcctcacacttggctttaatggtgtggctgc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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