Basic Information
VIS ID
TVIS44014210
Fusion event
HTLV-1-AGPAT3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
45385377/43965496 (Hg38)
End
45385377/43965496 (Hg38)
Orient
+
Location type
Intronic
Target gene
AGPAT3
miRNAs that regulate target gene
hsa-mir-744-5p ; hsa-mir-335-5p ; hsa-mir-26b-5p ; hsa-mir-24-3p ; hsa-mir-18a-3p ; hsa-mir-149-5p ; hsa-mir-100-5p ; hsa-mir-27a-3p ; hsa-mir-27b-3p ; hsa-mir-6744-3p ; hsa-mir-4757-5p
Nearest miRNA
hsa-let-7c/Upstream/355507; hsa-mir-6815/Downstream/1512770;
Nearest TSS
ENST00000624081/Upstream/567; ENST00000484865/Downstream/5907;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/5561, chr21-CpG: 19/Downstream/8015
Upstream sequence
tttggagccgtttaaacaacctggcccagcctcctcactccctgctgaccttggtcaaggcttcagtctctaaacctcagctttctcatctgcagagcac
Downstream sequence
agacaaaaccacctgcctttgagctgtcttataaagcctaaatcaatgcgcacagcaggtacacagcaatgcttgataaattgttactattattGGGTGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate