Basic Information
VIS ID
TVIS44014221
Fusion event
HTLV-1-GNPAT integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q42.2
Reference genome
GRCh37/hg19
Start
231388465/231252719 (Hg38)
End
231388465/231252719 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1H
Target gene
GNPAT
miRNAs that regulate target gene
hsa-mir-24-3p ; hsa-mir-331-3p
Nearest miRNA
hsa-mir-101-1/Upstream/232795; hsa-mir-1537/Downstream/2371433;
Nearest TSS
ENST00000473358/Upstream/11503; ENST00000492459/Downstream/13415;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/11222, chr1-CpG: 101/Downstream/84800
Upstream sequence
TCCTATTGCTCCATGCCCTCATTTTTTTCCTGGTCAGAAGAGAAAATATTCTTAAGAAACTCCTCTAAGGAATATGCTCTCTCCTTTTTTTTTTTTCTTT
Downstream sequence
TGGTCCTCTATAAATGTCTTAAAGGAAAACAAGCATGTATGCAACTAGTGTGTTTTTGTAAGGAGAGTGAACTCATTCAGAATTGCAGTATTCTTGCTTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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