Basic Information
VIS ID
TVIS44014261
Fusion event
HTLV-1-OXNAD1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p25.1
Reference genome
GRCh37/hg19
Start
16326562/16285055 (Hg38)
End
16326562/16285055 (Hg38)
Orient
+
Location type
Intronic
Target gene
OXNAD1
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-155-5p ; hsa-mir-16-5p ; hsa-let-7b-5p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-12127/Upstream/411206; hsa-let-7g/Downstream/648141;
Nearest TSS
ENST00000440867/Upstream/19589; ENST00000607464/Downstream/29384;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/19576, chr3-CpG: 113/Downstream/227765
Upstream sequence
TTGAACATGAAGGAAAGGGCTGGTGGTTGCTGATGGAGCAGTGTTTCTGAGAGAGTAGGCAGGACTAGGACCAAGAGTGCAGGTAGAGGGTCAGTAATGG
Downstream sequence
AAAATTACCCCAGTTGATTTTTAGGAGAGGAGCAAGAGAGGGTTGACAAAAATATGGAGAAAGAAAGGTTAGGTATTTTGCAGGAGGGAGAGAAAGGTAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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