Basic Information
VIS ID
TVIS44014262
Fusion event
HTLV-1-ZNF385D integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p24.3
Reference genome
GRCh37/hg19
Start
21852553/21811061 (Hg38)
End
21852553/21811061 (Hg38)
Orient
-
Location type
Intronic
Target gene
ZNF385D
miRNAs that regulate target gene
hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-6868-3p ; hsa-mir-627-3p ; hsa-mir-6734-3p ; hsa-mir-3667-3p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-2355-5p ; hsa-mir-3124-3p ; hsa-mir-5088-3p
Nearest miRNA
hsa-mir-12127/Upstream/1673420; hsa-let-7g/Downstream/3853812;
Nearest TSS
ENST00000440867/Upstream/33285; ENST00000448980/Downstream/131505;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/1624597, chr3-CpG: 86/Downstream/560940
Nearby gene
ZNF385D(-59737) ;
Upstream sequence
gtgtgtatacgtgtgtgtgtgtgtgtgtgtgtgtgtgtatatatatatacatTTTAAGTAAGTAATTAATGTAATTAATGTCTTTAGCAACCAGGATTTC
Downstream sequence
CACATAGGAAATATAAAGAAAAGAGATACAAATGCAAAGAATCAAAGAATTTAATAAAAATAATCTCAAATCTTAAATCAGAATTGAAAATATCCGTATA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate