Basic Information
VIS ID
TVIS44014264
Fusion event
HTLV-1-ADAMTS9 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p14.1
Reference genome
GRCh37/hg19
Start
64577829/64592153 (Hg38)
End
64577829/64592153 (Hg38)
Orient
-
Location type
Intronic
Target gene
ADAMTS9
miRNAs that regulate target gene
hsa-mir-29a-3p ; hsa-mir-183-3p ; hsa-mir-3613-3p ; hsa-mir-7-2-3p ; hsa-mir-5688 ; hsa-mir-7-1-3p ; hsa-mir-495-3p ; hsa-mir-3609 ; hsa-mir-548ah-5p ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-297 ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-3941 ; hsa-mir-223-5p ; hsa-mir-567 ; hsa-mir-511-3p ; hsa-mir-5011-5p ; hsa-mir-4789-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485
Nearest miRNA
hsa-let-7g/Upstream/3974283; hsa-mir-12124/Downstream/2633311;
Nearest TSS
ENST00000440867/Upstream/8300; ENST00000485174/Downstream/23997;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/146637, chr3-CpG: 182/Downstream/93258
Nearest cancer related gene
ADAMTS9(TSG, No orient, 0)
Upstream sequence
CAATTAAAATCAAAACTCTACAGTAAGAATCTGAAAGACTGCCCTCTCACTCATATATTTAGGAAAAGTAATATATTACAAAGATATTTTAAAGAAAATG
Downstream sequence
CTTTTGATTTAATTTTTTAAGATCACAATTAAAAGCCTTGCAGAAGTGGCCTTGCTCTTAGACTGTAGAGGCTTCGCATATTTGAATAATGATCACTTTA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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