Basic Information
VIS ID
TVIS44014285
Fusion event
HTLV-1-SLC35B4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q33
Reference genome
GRCh37/hg19
Start
133981475/134296723 (Hg38)
End
133981475/134296723 (Hg38)
Orient
-
Location type
Intronic
Target gene
SLC35B4
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-215-5p ; hsa-mir-181a-5p ; hsa-mir-192-5p ; hsa-mir-744-5p ; hsa-mir-182-3p ; hsa-mir-26a-5p ; hsa-mir-6844 ; hsa-mir-3941 ; hsa-mir-4796-5p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-1295b-3p ; hsa-mir-129-5p ; hsa-mir-8055 ; hsa-mir-6794-3p ; hsa-mir-6879-3p ; hsa-mir-215-3p ; hsa-mir-6773-3p ; hsa-mir-1304-3p ; hsa-mir-4639-3p ; hsa-mir-500b-3p ; hsa-mir-5007-5p ; hsa-mir-3664-5p
Nearest miRNA
hsa-mir-10525/Upstream/1005735; hsa-mir-10399/Downstream/910271;
Nearest TSS
ENST00000635602/Upstream/1546; ENST00000475559/Downstream/20174;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/169243, chr7-CpG: 75/Downstream/19732
Upstream sequence
CAGGCTATAGCAGCCACTAAAGTCATTAAATTGGTTTCTTAAAACAAATAATAGTTTTAATTTTTAAGGAAGTGTTTTACCATTTGCCTGAATAGTACCT
Downstream sequence
CACTTTACAAAGAAAGACTGTGAAGCACAGAAAAGTTGAAAATgataaaatgatatagacagccttaacaactcaacacaagaggaaaggcggctagcaa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate