VISDB - VIS Detail

Basic Information

VIS ID

TVIS44014299

Fusion event

HTLV-1-GALNT8 integration

Validated

No

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2014

PubMed ID

24735963

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr12

Cytoband

p13.32

Reference genome

GRCh37/hg19

Start

4858926/4749760 (Hg38)

End

4858926/4749760 (Hg38)

Orient

+

Location type

Intronic

Target gene

GALNT8

miRNAs that regulate target gene

hsa-mir-4446-5p ; hsa-mir-4804-3p ; hsa-mir-627-3p ; hsa-mir-7-2-3p ; hsa-mir-5688 ; hsa-mir-7-1-3p ; hsa-mir-495-3p ; hsa-mir-591 ; hsa-mir-676-5p ; hsa-mir-6756-3p ; hsa-mir-3127-3p ; hsa-mir-4289 ; hsa-mir-4714-3p ; hsa-mir-6769a-3p ; hsa-mir-501-5p ; hsa-mir-7151-5p

Nearest miRNA

hsa-mir-3649/Upstream/3089380; hsa-let-7i/Downstream/2213939;

Nearest TSS

ENST00000382841/Upstream/29419; ENST00000535354/Downstream/13584;

Nearest CpG islands

None/Target, chr12-CpG: 104/Upstream/100495, chr12-CpG: 137/Downstream/59347

Upstream sequence

agggtaatactggcctcatagaatgagtttggaaatgttccctcctgtattttttggaaaaatttaagtaggattggtactagtttttctttaaatattc

Downstream sequence

ggtagaaatcaacagtgaaaccactgagtcccaggttttcctttactgggagactttttattacagctttgatctcattacttgttattgttctgttcag

Reference

Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.