Basic Information
VIS ID
TVIS44014300
Fusion event
HTLV-1-CACNA2D3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p14.3
Reference genome
GRCh37/hg19
Start
54827783/54793756 (Hg38)
End
54827783/54793756 (Hg38)
Orient
+
Location type
Intronic
Target gene
CACNA2D3
miRNAs that regulate target gene
hsa-mir-18a-3p ; hsa-mir-8058 ; hsa-mir-4529-3p ; hsa-mir-5009-5p ; hsa-mir-1269b ; hsa-mir-1269a ; hsa-mir-6516-3p ; hsa-mir-92a-1-5p ; hsa-mir-6503-3p ; hsa-mir-8075 ; hsa-mir-8069 ; hsa-mir-664a-3p ; hsa-mir-758-5p ; hsa-mir-4728-3p ; hsa-mir-6074
Nearest miRNA
hsa-let-7g/Upstream/1947204; hsa-mir-12124/Downstream/1058736;
Nearest TSS
ENST00000440867/Upstream/520982; ENST00000471865/Downstream/107499;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/167145, chr3-CpG: 24/Downstream/676417
Nearest cancer related gene
CACNA2D3(TSG, No orient, 0)
Upstream sequence
CTTTGTCTAGGTCAGTGTAGTGCAGTGGCTTTGTAGAGAAAGCTGGGttgtatttgtttgtcgggttttaataatgctgatgtaataaaatgagttggga
Downstream sequence
tgtatttccttctttattttctaaaacatgtttttgttagattgctgtatttcttcttgaatgtttgttagaattcattaatgaaactatttgagcctgg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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