Basic Information
VIS ID
TVIS44014304
Fusion event
HTLV-1-TRIM14 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q22.33
Reference genome
GRCh37/hg19
Start
100866884/98104602 (Hg38)
End
100866884/98104602 (Hg38)
Orient
-
Location type
Intronic
Target gene
TRIM14
miRNAs that regulate target gene
hsa-mir-7-5p ; hsa-mir-320a ; hsa-mir-659-3p ; hsa-mir-450a-1-3p ; hsa-mir-4425 ; hsa-mir-656-5p ; hsa-mir-6739-5p ; hsa-mir-6733-5p ; hsa-mir-3153 ; hsa-mir-4668-5p ; hsa-mir-4261 ; hsa-mir-9-5p ; hsa-mir-4640-3p ; hsa-mir-3591-3p ; hsa-mir-21-3p ; hsa-mir-15b-5p
Nearest miRNA
hsa-let-7a-1/Upstream/740921; hsa-mir-12126/Downstream/124547;
Nearest TSS
ENST00000422679/Upstream/16601; ENST00000610463/Downstream/14534;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/16492, chr9-CpG: 63/Downstream/14214
Upstream sequence
GCAATATGGTCAGAAAGGGGTagagagagagagggaaggggagagagagagagagaaagagagcaagagaATATCATGGTCATGAAATAAGGAAGTACGC
Downstream sequence
CATCTGGTTTGGGTCCCACTGGTTCAAAGTGAAGATCCCAGCTGAACTGGGCTGGGCTTTGAAGAGAGCTGGTGGCTGGGTGAGGGCCTAACAGAGTCTA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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