Basic Information
VIS ID
TVIS44014308
Fusion event
HTLV-1-chr5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
61583244/62287417 (Hg38)
End
61583244/62287417 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA5H
Nearest miRNA
hsa-mir-10397/Upstream/2583714; hsa-mir-103a-1/Downstream/9882050;
Nearest TSS
ENST00000502646/Upstream/409308; ENST00000512541/Downstream/18745;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/660772, chr5-CpG: 141/Downstream/18373
Nearby gene
KIF2A(+18745) ;
Upstream sequence
GGACAGGACCGGACAGAGTCAGAGGGAGACCAGACCTATAAGGCAATCCCTGCCTTCCCTTCTAGTGAACTTCAACCTAGTGAACCAGAAAAGGGAGGGG
Downstream sequence
AGGAAGAGTGAAAGAGCTGACTTTGAAGGTGCTTGGACCATGAGTCAAGCCTCAGATGGGGAAGTAGAGACGTGATTGGAGTCATAATCGAATTCTCCAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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