Basic Information
VIS ID
TVIS44014313
Fusion event
HTLV-1-GRK5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q26.11
Reference genome
GRCh37/hg19
Start
120982968/119223456 (Hg38)
End
120982968/119223456 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10F ; FRA10A ; FRA10B
Target gene
GRK5
miRNAs that regulate target gene
hsa-mir-941 ; hsa-mir-4758-5p ; hsa-mir-1238-5p ; hsa-mir-4481 ; hsa-mir-4745-5p ; hsa-mir-570-3p
Nearest miRNA
hsa-mir-107/Upstream/2055682; hsa-mir-202/Downstream/154516;
Nearest TSS
ENST00000439456/Upstream/15867; ENST00000369108/Downstream/112501;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/15345, chr10-CpG: 181/Downstream/318510
Upstream sequence
cataatcttctttggaggacgcagtGAACCCTGGAACACAGGCCCTGCCTGTACTGAAGCAGCAGCTTTTGGGGATAGCCTGTATTTTTAAAACAGGAGG
Downstream sequence
TTCTGAGGATGAACCAGGCGTGGGAACTGCTGCTCTATAGAACCCTGGAGCTGGTGGGTTTTCTGAGTGCCTTCTGAGATTATCTTGGACATCCAGACTA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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