Basic Information
VIS ID
TVIS44014348
Fusion event
HTLV-1-CARD14 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
78182142/80208343 (Hg38)
End
78182142/80208343 (Hg38)
Orient
-
Location type
Exonic
Target gene
CARD14
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-26b-5p
Nearest miRNA
hsa-mir-10226/Upstream/109466; hsa-mir-1250/Downstream/211075;
Nearest TSS
ENST00000595228/Upstream/2394; ENST00000574967/Downstream/1199;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/9740, chr17-CpG: 46/Downstream/2161
Upstream sequence
CCTGACGGCTGGAGCGACCTGGACGGCCTGCTCAGCTGTGTCCGCCAGGCCATCGCCGACGAGCAGAAGAAGGTGGTGTGGACGGAGCAGAGCCCCCGAT
Downstream sequence
GATGCACCGTGCCCCTTCCCGGGACTGTGGGGGCTTCTGTGTGCCTGTTAATGCAGTCCTGTTCCTCAGCCCAGGCCCTCTTGGCACAGCTGTGGGCTCC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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