Basic Information
VIS ID
TVIS44014364
Fusion event
HTLV-1-STIM1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p15.4
Reference genome
GRCh37/hg19
Start
3881338/3860108 (Hg38)
End
3881338/3860108 (Hg38)
Orient
+
Location type
Intronic
Target gene
STIM1
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-let-7b-5p ; hsa-mir-769-3p ; hsa-mir-17-3p ; hsa-mir-1231 ; hsa-mir-620 ; hsa-mir-1270 ; hsa-mir-3650 ; hsa-mir-4711-3p ; hsa-mir-4683 ; hsa-mir-1273f ; hsa-mir-6776-5p ; hsa-mir-6861-5p ; hsa-mir-4638-5p ; hsa-mir-6793-3p ; hsa-mir-185-5p ; hsa-mir-185-3p ; hsa-mir-1180-3p ; hsa-mir-1226-5p ; hsa-mir-1304-5p ; hsa-mir-1914-3p ; hsa-mir-3184-5p ; hsa-mir-423-5p ; hsa-mir-4778-3p ; hsa-mir-5194 ; hsa-mir-6734-5p ; hsa-mir-6738-5p ; hsa-mir-6783-5p ; hsa-mir-6834-5p ; hsa-mir-6850-3p ; hsa-mir-6875-3p ; hsa-mir-8055
Nearest miRNA
hsa-mir-210/Upstream/3967; hsa-let-7a-2/Downstream/3374658;
Nearest TSS
ENST00000527297/Upstream/3926; ENST00000524822/Downstream/6995;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/3907, chr11-CpG: 68/Downstream/234351
Upstream sequence
ctgtggggatttaaggatgaacaaaacagacatgttccttccctcatggaagttacagtcttgttgatgagacagataataaacacataaataaatatat
Downstream sequence
tatcttgtggaaaatgtcatggaagaaataaacaggatgctatcatggagaatgagaggggaacaGAGATCTAGTTAAAGCCTGAACCTAATTGTAGGAC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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