Basic Information
VIS ID
TVIS44014384
Fusion event
HTLV-1-SKOR1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q23
Reference genome
GRCh37/hg19
Start
68118422/67826084 (Hg38)
End
68118422/67826084 (Hg38)
Orient
+
Location type
Exonic
Target gene
SKOR1
miRNAs that regulate target gene
hsa-mir-6848-3p ; hsa-mir-6843-3p ; hsa-mir-323a-5p ; hsa-mir-4483 ; hsa-mir-1293 ; hsa-mir-6793-3p
Nearest miRNA
hsa-mir-10393/Upstream/1329050; hsa-mir-11181/Downstream/975766;
Nearest TSS
ENST00000557528/Upstream/539; ENST00000564915/Downstream/12795;
Nearest CpG islands
chr15-CpG: 534/Target, None/Upstream, None/Downstream
Upstream sequence
GGCAGTTCCTCGCCCAACTCCAAGCAGGAGCTGCAGCCGTACTCGGGCTCCAGCGCTCTCAAACCCAACCAGGTGGGCGAGACGTCGCTGTACGGGGTGC
Downstream sequence
CCATTGTGTCGCTGGTCATCGACGGCCAGGAGCGCCTATGCCTGGCGCAGATCTCCAACACCCTCCTCAAGAACTACAGCTATAATGAGATCCACAACCG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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