VISDB - VIS Detail

Basic Information

VIS ID

TVIS44014417

Fusion event

HTLV-1-TECPR2 integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2014

PubMed ID

24735963

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr14

Cytoband

q32.31

Reference genome

GRCh37/hg19

Start

102839371/102373034 (Hg38)

End

102839371/102373034 (Hg38)

Orient

Location type

Intronic

Target gene

TECPR2

miRNAs that regulate target gene

hsa-mir-92a-3p ; hsa-mir-32-5p ; hsa-mir-92b-3p ; hsa-mir-143-5p ; hsa-mir-3944-5p ; hsa-mir-6845-5p ; hsa-mir-6762-5p ; hsa-mir-6508-3p ; hsa-mir-6722-3p ; hsa-mir-1909-3p ; hsa-mir-6836-5p ; hsa-mir-6132 ; hsa-mir-4742-3p ; hsa-mir-4793-5p ; hsa-mir-5196-3p ; hsa-mir-500b-5p ; hsa-mir-362-5p ; hsa-mir-216b-5p ; hsa-mir-216a-5p ; hsa-mir-4737 ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-629-3p ; hsa-mir-6818-3p ; hsa-mir-4507 ; hsa-mir-3940-5p ; hsa-mir-6873-3p ; hsa-mir-6867-3p ; hsa-mir-4713-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-642a-5p ; hsa-mir-494-5p ; hsa-mir-410-5p ; hsa-mir-323b-5p ; hsa-mir-942-5p ; hsa-mir-600 ; hsa-mir-29a-5p ; hsa-mir-3920 ; hsa-mir-6845-3p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-7113-3p ; hsa-mir-4469 ; hsa-mir-6832-3p ; hsa-mir-5088-3p ; hsa-mir-2276-5p ; hsa-mir-6892-3p ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-6756-3p ; hsa-mir-3127-3p ; hsa-mir-4715-3p ; hsa-mir-6071 ; hsa-mir-6829-5p ; hsa-mir-6882-3p ; hsa-mir-661 ; hsa-mir-6781-3p ; hsa-mir-2682-3p ; hsa-mir-3692-5p ; hsa-mir-93-3p ; hsa-mir-6728-3p ; hsa-mir-7107-5p ; hsa-mir-6852-5p ; hsa-mir-1234-3p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-15b-5p

Nearest miRNA

hsa-mir-1185-1/Upstream/812612; hsa-mir-12121/Downstream/166610;

Nearest TSS

ENST00000550708/Upstream/9955; ENST00000560060/Downstream/61805;

Nearest CpG islands

None/Target, chr14-CpG: 35/Upstream/9498, chr14-CpG: 309/Downstream/133946

Upstream sequence

ATAGTGAGCATTTATAACTGTTATAAAAAGAAACCtttatttttaaaaagttaaataaattatGGCACATCAATGTGTGTATGAGTATGTATGTATGCAC

Downstream sequence

TCTTTAAGGAAACAAAGCCTTTTACTATTTCTGTGCCTTGGAAAGAAGAATAAGAAGTTTCTGCATCCATGAAGTGGAGGTAACATTCATGTCTAATGTT

Reference

Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.