Basic Information
VIS ID
TVIS44014418
Fusion event
HTLV-1-GIT1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
27903915/29576897 (Hg38)
End
27903915/29576897 (Hg38)
Orient
+
Location type
Exonic
Target gene
GIT1
miRNAs that regulate target gene
hsa-mir-7-5p ; hsa-mir-484 ; hsa-mir-149-5p ; hsa-mir-491-5p ; hsa-mir-34c-5p ; hsa-mir-125a-3p
Nearest miRNA
hsa-mir-1180/Upstream/186167; hsa-mir-10226/Downstream/540182;
Nearest TSS
ENST00000595228/Upstream/463; ENST00000578811/Downstream/74;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/3848, chr17-CpG: 116/Downstream/11803
Upstream sequence
AGCTGGGCCTCAGCGAAGGCCTGGGTCAGGGCACAGGGGAGTGGGAAGGAGGGTGGGACTCAGACCCGGGCCCGGTTGCTCCGAGTGGCGCCGGTGCTGC
Downstream sequence
GCAGGGGCTCCTGGTCTGTGTCCTCGTCAGAGGCCACGCTGTCGTAGTCGTGTTGGTCGTCGAGGTCACTCTGGCTCCGCAGAGACAGCTCGAGGTTGTC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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