Basic Information
VIS ID
TVIS44014422
Fusion event
HTLV-1-COX7A2L integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p21
Reference genome
GRCh37/hg19
Start
42587756/42360616 (Hg38)
End
42587756/42360616 (Hg38)
Orient
+
Location type
Intronic
Target gene
COX7A2L
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-324-3p ; hsa-mir-218-5p ; hsa-mir-767-5p ; hsa-mir-302d-5p ; hsa-mir-302b-5p ; hsa-mir-6501-3p ; hsa-mir-330-3p ; hsa-mir-29c-3p ; hsa-mir-29b-3p ; hsa-mir-29a-3p ; hsa-mir-6835-3p
Nearest miRNA
hsa-mir-1301/Upstream/6889130; hsa-mir-10b/Downstream/5017059;
Nearest TSS
ENST00000437798/Upstream/578; ENST00000433553/Downstream/533;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/190823, chr2-CpG: 61/Downstream/316
Upstream sequence
TCAAATATTTTACAATCGGGAAAGTGTAACCTCGCTGCATGCAACTTCCCTCCCTGGACGTGTTAAGTAACCTGTTAAATTTCCCAACCCAGATCATAGC
Downstream sequence
CCCCCAACCCCCTGCACCATGGTTTCTCTAAACGCCTTTATAGCCCCGCGCTCTCTAATCTCGAGCTCAAGTGAGGCTGCCTATGGGGCTCTGGCAGATG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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