Basic Information
VIS ID
TVIS44014424
Fusion event
HTLV-1-A4GALT integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
43094653/42698647 (Hg38)
End
43094653/42698647 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA22A
Target gene
A4GALT
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-483-3p ; hsa-mir-4314 ; hsa-mir-4279 ; hsa-mir-7111-3p ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-3192-5p ; hsa-mir-4646-5p ; hsa-mir-204-3p ; hsa-mir-330-5p ; hsa-mir-326 ; hsa-mir-6817-3p ; hsa-mir-6845-3p ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-3183 ; hsa-mir-5193
Nearest miRNA
hsa-mir-1281/Upstream/775350; hsa-let-7a-3/Downstream/2502307;
Nearest TSS
ENST00000624155/Upstream/3014; ENST00000443063/Downstream/22172;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/4985, chr22-CpG: 107/Downstream/21498
Upstream sequence
GCCCTCCATCCAGGCTGAGTGCTGACAGAGAGGCTCCCAGAGCACCAGGGTTATGCCCTTGGAGATTCCGATGTCCTGACGGGAACACAGAGGCCCCGAG
Downstream sequence
AGGCAAAGGtgtcagaggcgtgtgagccagaccaacaccatcttaaataggagctgagtaaaatgaggctgacacctactgggctgcattcccagacggg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate