Basic Information
VIS ID
TVIS44014428
Fusion event
HTLV-1-EDA integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
68852636/69632792 (Hg38)
End
68852636/69632792 (Hg38)
Orient
+
Location type
Intronic
Target gene
EDA
miRNAs that regulate target gene
hsa-let-7f-5p
Nearest miRNA
hsa-let-7f-2/Upstream/3613813; hsa-mir-105-1/Downstream/390065;
Nearest TSS
ENST00000429181/Upstream/12336; ENST00000616899/Downstream/324232;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/15573, chrX-CpG: 76/Downstream/429742
Upstream sequence
tctgcaaatccattcccctcactaactataataccacctatggattttactccatttgcccccactcttgtgctcctgtctccatagaggaaatgtgttc
Downstream sequence
ctttggttcaagaccagtccttttatctgagctttggatcttctccccgcttactatctcatggtcctttctcttagtcattttcttcctatcctgtatc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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