Basic Information
VIS ID
TVIS44014432
Fusion event
HTLV-1-SLCO1B3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
p12.2
Reference genome
GRCh37/hg19
Start
21001607/20848673 (Hg38)
End
21001607/20848673 (Hg38)
Orient
-
Location type
Intronic
Target gene
SLCO1B3
miRNAs that regulate target gene
hsa-mir-6867-3p ; hsa-mir-188-3p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-7113-3p ; hsa-mir-4469 ; hsa-mir-532-3p ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-4639-3p ; hsa-mir-4457 ; hsa-mir-3936 ; hsa-mir-1277-5p ; hsa-mir-4789-5p ; hsa-mir-3941 ; hsa-mir-5011-5p ; hsa-mir-4789-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-190a-3p ; hsa-mir-340-5p ; hsa-mir-5590-3p ; hsa-mir-142-5p
Nearest miRNA
hsa-mir-1244-3/Upstream/3175279; hsa-let-7i/Downstream/3363748;
Nearest TSS
ENST00000382841/Upstream/32999; ENST00000545880/Downstream/6419;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/295603, chr12-CpG: 34/Downstream/588862
Upstream sequence
aagcaaccaagatatctttcaataggtgaataggtaaagaaactgtgatacagtcaaacaatgtaattttttttagtgattaaaaagaaatggaacatca
Downstream sequence
agtcataaaaatacatggaaagacatccaaaacataactgtaagcaaagaagcaaatcttaaaatgttatatattgtaagatttcaaatatatgagattc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate