Basic Information
VIS ID
TVIS44014444
Fusion event
HTLV-1-TSHZ2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
51605107/52988568 (Hg38)
End
51605107/52988568 (Hg38)
Orient
+
Location type
Intronic
Target gene
TSHZ2
miRNAs that regulate target gene
hsa-mir-4423-5p ; hsa-mir-6501-5p ; hsa-mir-891a-3p ; hsa-mir-143-5p ; hsa-mir-5698 ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-593-5p ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-6499-3p ; hsa-mir-767-5p ; hsa-mir-367-5p ; hsa-mir-1267 ; hsa-mir-6787-3p ; hsa-mir-5693 ; hsa-mir-6736-3p ; hsa-mir-6830-3p ; hsa-mir-6809-3p ; hsa-mir-6875-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-4775 ; hsa-mir-6873-3p ; hsa-mir-6845-3p ; hsa-mir-942-5p ; hsa-mir-590-3p ; hsa-mir-744-3p ; hsa-mir-4772-3p ; hsa-mir-1281 ; hsa-mir-6890-3p ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p
Nearest miRNA
hsa-mir-103a-2/Upstream/1535591; hsa-mir-1-1/Downstream/1079840;
Nearest TSS
ENST00000382410/Upstream/16161; ENST00000329613/Downstream/190982;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/15087, chr20-CpG: 26/Downstream/592951
Upstream sequence
CATGCTTAACAGCACAGACTCACATAAATAAACTTCCACAATATAGTATAGATACATGGAGGCTAAGGCCATGAACTGAAATTTAGTGTTTCCCCAGGTT
Downstream sequence
GAAGTAAGTCAATTGTGTTGTAGAAAAAAAAAAAAAAGATCATCCCTACTTATTTAAATCCCCAAACACCATCTTTAAAACTTGAGCCTATGAAGAAAAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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